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    Autoimmune and inflammatory animal models

    Autoimmune and Inflammation Models 

    1) Autoimmune arthritis

  • Collagen induced arthritis (CIA) in DBA/1 mice
  • Adjuvant induced arthritis (AIA) in Lewis rats
  • hTNFα transgenic mice - a spontaneous model
  • 2) Experimental autoimmune encephalomyelitis

    3) Delayed type hypersensitivity (DTH)

  • Oxazolone-induced DTH in mice
  • DNFB-induced DTH in mice
  • 4) Psoriasis-Imiquimod-induced psoriasis-like skin inflammation 

    5) IBD-Naive T cell transfer induced Colitis

    6) Systemic lupus erythematosusSLEin MRL mice

     

    Rheumatoid Arthritis (RA) Models     

  • Collagen-induced arthritis (CIA) in DBA/1 mice
  • Collagen-induced arthritis (CIA) in Lewis rats
  • Adjuvant-induced arthritis (AIA) in Lewis rats
  • hTNFa transgenic mice
  •  

    Multiple Sclerosis (MS) Models

  • MOG-induced (experimental autoimmune encephalomyelitis, EAE) in C57BL/6 mice
  • MBP-induced EAE in Lewis rats
  • PLP-induced relapsing-remitting EAE in SJL mice
  •  

    Delayed Type Hypersensitivity (DTH) Models              

  • Oxazolone-induced DTH in mice
  • DNFB-induced DTH in mice
  •  

    Psoriasis Model

  • Imiquimod-induced psoriasis-like skin inflammation in mice
  • IL-23-induced eczema in mice
  •  

    Inflammatory Bowel Disease (IBD) Model

  • DSS-induced colitis in C57BL/6 mice
  • TNBS-induced colitis in mice
  •  

    Gout Models

  • Oteracil potassium-induced hyperuricemia
  • MSU-induced air pouch inflammation
  •  

    Acute Inflammation In Vivo

  • LPS-induced airway inflammation in Wistar rats
  • LPS-induced cytokine model in mice and rats
  • ConA-induced cytokine model in mice and rats
  • R848 (Resiquimod) induced cytokine model in mice and rats
  •  

    In Vitro Assays

  • Cell based in vitro screening (PBMC)
  • Cell based in vitro screening (Cell line and Multiplex)
  •  

    Business Contact 

  • North America: Declan Ryan,  declan.ryan@wuxiapptec.com
  • Europe and Israel: Dave Madge,  dave_madge@wuxiapptec.com
  • China: Marcher Xu,  xu_longji@wuxiapptec.com
  • Japan: Yan Zhu,  yan_zhu@wuxiapptec.com
  • Korea: Suk Young Cho,  sycho@wuxiapptec.com